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Door 01 · Research services

Questions in, evidence out.

Five services on the HNEV™ Regenerative RNA Platform — designed to be used alone or chained into one programme, with documentation at every gate.

5specialised services
01miRNA & siRNA research

RNA profiling

Structured molecular profiling for research and translational programmes — deep insight into what RNA is doing and where.

  • Differential miRNA expression (qPCR / NGS)
  • Exosome-derived miRNA panels
  • Inflammation, oxidative-stress and regenerative markers
  • Collagen and ECM-related miRNA profiling
  • Comparative RNA mapping — plant versus MSC vesicles
  • Pathway evaluation: Wnt, TGF-β, NF-κB, MAPK, PI3K/Akt

You receive

  • Expression report
  • Pathway interpretation
  • Raw-data summary
02RNA-based translational research

Diagnostic research

Support for RNA biomarker development and vesicle-associated RNA analysis, designed for early detection research.

  • miRNA biomarker validation studies
  • Research-use diagnostic panel development
  • Circulating EV RNA profiling
  • RNA extraction and quantification
  • In-vitro siRNA gene-silencing
  • Functional validation: collagen, melanin, cytokines

You receive

  • Validation report
  • Panel data
  • Functional read-outs
03RNA–exosome integration

Cargo loading

Controlled loading of RNA into plant- or MSC-derived vesicles, with proof that it arrived — and stayed — intact.

  • RNA loading into plant or MSC vesicles
  • Encapsulation-efficiency assessment
  • Vesicle–RNA interaction profiling
  • Stability evaluation
  • In-vitro delivery studies
  • Release-kinetics assessment

You receive

  • Loading protocol
  • Efficiency data
  • Stability & release report
04Research and GMP-aligned production

Vesicle production

Plant- and MSC-derived vesicles (30–200 nm) produced to a defined concentration, scalable from research to regulated programmes.

  • Controlled nanoscale vesicle production
  • Standardised concentration (≥ 1 × 10⁹ EVs/mL)
  • Research-grade and GMP-aligned production
  • Batch scalability and documentation support

You receive

  • Batch record
  • COA & MSDS
  • Analytical summary
05Identification & characterisation

Release testing

The measurements that prove what a vesicle preparation is, and that it is safe to use.

  • Physical: NTA, size (30–200 nm), TEM/SEM morphology
  • Molecular: biomarkers, RNA integrity, protein
  • Safety: sterility, endotoxin, mycoplasma, microbial load, aflatoxin & pesticides
  • Documentation: COA, MSDS, analytical summary

You receive

  • Full test report
  • COA
  • MSDS
One programme

From vesicle to validated delivery.

A typical end-to-end programme moves left to right, with a documented output at every gate.

Brief

Objective, source, grade, timelines, confidentiality.

Produce

Vesicles at a defined concentration.

Characterise

NTA, TEM/SEM, biomarkers, safety release.

Load & profile

RNA cargo loading and miRNA profiling.

Evaluate

Delivery, release, functional outcomes, report.

Find your starting point

Which service answers your question?

Your questionServiceTypical output
Which miRNAs drive the effect we see?RNA profilingDifferential expression, pathway evaluation
Can EV-associated RNA be a biomarker?Diagnostic researchBiomarker validation, research-use panels
Can our RNA be delivered inside vesicles?Cargo loadingLoading, encapsulation efficiency, release kinetics
We need vesicles at a defined concentrationVesicle production≥ 1 × 10⁹ EVs/mL, research or GMP-aligned
Is this vesicle what we think — and safe?Release testingNTA, TEM/SEM, safety screen, COA, MSDS
Plant or MSC — which carries our signal?RNA profilingSide-by-side miRNA maps of plant and MSC vesicles
Engagement

Three ways to engage.

Project

A defined question

Fixed scope, timeline and deliverables — ideal for a single profiling, loading or testing study.

Programme

A chained pathway

Production, characterisation, loading and evaluation run as one documented programme.

Co-development

A shared product

We build with you toward a finished ingredient or product, with services feeding each stage.

Services FAQ

What teams ask us.

Who are these services for?

Formulation and R&D teams in cosmetics and dermatology, regenerative-medicine researchers, diagnostics groups working with EV-associated RNA, and developers who need a partner to make and characterise vesicles to a defined specification.

Can services be combined into one programme?

Yes — a common chain is produce → characterise → load → evaluate delivery. Each stage is documented so it can stand alone or feed the next.

What do we receive at the end?

A written report with methods, data summaries and conclusions, plus COA and MSDS where material is supplied — designed to slot into your R&D or regulatory file.

Do you work under NDA?

Yes. Confidentiality agreements are standard; arrange one before sharing project details.

Is clinical work offered?

Services are research-stage: in vitro, analytical and production. For clinical development we can supply well-characterised vesicles to your programme’s specification.

Start an enquiry

Describe the question. We’ll scope the study.

Research question, bulk requirement or a product for your brand — we’ll route it to the right team and reply with a clear next step.